There’s a big NFC game to kick off Week 5 of the 2025 NFL season. The Los Angeles Rams are off to a hot start, racking up a 3-1 record. They’d be undefeated had they not blown a significant lead against the Philadelphia Eagles a couple weeks back. Speaking of backs, Matthew Stafford looks like himself despite battling a back injury for most of the offseason. Stafford has an arsenal of weapons at his disposal and a young, aggressive defense to help give him the ball back.
Things aren’t quite as optimistic for the San Francisco 49ers, despite the fact that they, too, are 3-1 to start the season. That largely has to do with one thing: injuries. The following players won’t play for the 49ers on Thursday:
- QB Brock Purdy
- WR Jauan Jennings
- WR Ricky Persall
- TE George Kittle
- EDGE Nick Bosa
… among plenty of others. As a result, the home Los Angeles Rams are 7.5-point favorites on Thursday night.
Seeing as this is a matchup between two NFC contenders, Detroit Lions fans should be watching closely. One of these teams could very well be facing off against Detroit come January. Plus, the Lions face off against the Rams in Week 15. So if you’re down to get some early scouting in, come watch the game with us on Thursday night. Here’s how to tune in:
49ers at Rams
Date: Thursday, Oct. 2, 2025
Time: 8:15 p.m. ET
Location: SoFi Stadium — Los Angeles, CA
TV (stream): Amazon Prime
Announcers: Al Michaels, Kirk Herbstreit
Additional online Streaming: NFL Sunday Ticket via YouTube, NFL+ Premium
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