The Buffalo Bills will hope to add a win to their record in 2024 in Week 1. The team will host the Arizona Cardinals at Highmark Stadium.

As usual, it will never be a walk in the park in the NFL. If the Bills expect to beat the Cardinals, there will be few key things Buffalo will have to focus on against Arizona.

It will have to be a full-team effort, make no mistake. But these factors could weigh heavy on whether or not Buffalo sends Arizona home with a win or loss.

Here are three keys to the Bills pulling out a victory against the Cards:

Play clean

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We’re looking at you, Josh.

We’re also not here to say he’s overrated by any means. But Allen does turn the ball over. In his last two season openers, he tossed five interceptions combined. That’s why Buffalo was upset by the New York Jets.

On a positive: This game is at home and those two were not. Always a big boost for the Bills.

Attack Kyler

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While the Bills offense and starters barely got any playing time in the preseason (in part due to weather), the Cardinals’ first teamers got even less, including quarterback Kyler Murray. They did not play a single snap.

To each their own, but Murray was held to only eight games in 2023 due to injury. He has not played for a long while. Buffalo defensive coordinator Bobby Babich should get getting the green light to put Murray under pressure early and often.

Lean on Khalil

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It’s simple. The only wide receiver to catch a pass from Allen in the regular season on the Bills roster? Khalil Shakir. Allen and offensive coordinator Joe Brady should be looking to jump on that Shakir wagon while the chemistry with other wideouts is built up.