One of the best quarterbacks in the NFL last season will be on show when Josh Allen and the Buffalo Bills host the Arizona Cardinals on Sunday, September 8, 2024.

The Bills ranked ninth in total defense last year (307.2 yards allowed per game), but they played really well on offense, ranking fourth-best in the NFL with 374.5 total yards per game. The Cardinals averaged 324.1 yards per game on offense last year (19th in NFL), and they surrendered 355.7 yards per game (25th) on the defensive side of the ball.

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Bills vs Cardinals: live streaming info, TV channel & game time

Bills vs Cardinals betting lines

NFL odds courtesy of BetMGM. Odds updated Saturday at 3:22 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

  • Spread Favorite: Bills (-6.5)
  • Moneyline: Bills (-301), Cardinals (+241)
  • Total: 47 points

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