Buffalo Bills at Detroit Lions odds, picks and predictions

The Buffalo Bills (10-3) take on the Detroit Lions (12-1) Sunday in Week 15. Kickoff from Ford Field is set for 4:25 p.m. ET (CBS). Below, we look at Bills vs. Lions odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.
The Bills were marched out of town by the LA Rams in a 44-42 defeat in Week 14. They made a late push, down 38-21 in the fourth quarter, but it wasn’t enough. QB Josh Allen had a huge game, going 22-for-37 for 342 yards, 3 TDs and 0 INTs while rushing 10 times for 82 yards and 3 more TDs.
The Lions won their 11th straight in a 34-31 win over the Green Bay Packers Dec. 5. QB Jared Goff was 32-for-41 for 283 yards, 3 TDs and 1 INT. He spread the ball around to 6 different receivers that had 5 grabs apiece. WR Tim Patrick introduced himself with a 6-43-2 evening.
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Bills at Lions odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 5:42 p.m. ET.
- Moneyline (ML): Bills +120 (bet $100 to win $120) | Lions -145 (bet $145 to win $100)
- Against the spread (ATS): Bills +2.5 (-110) | Lions -2.5 (-110)
- Over/Under (O/U): 54.5 (O: -110 | U: -110)
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Bills at Lions key injuries
Bills
- CB Rasul Douglas (knee) out
- S Damar Hamlin (back, ribs) questionable
- TE Dalton Kincaid (knee) questionable
- S Taylor Rapp (neck, shoulder) questionable
Lions
- LB Trevor Nowaske (concussion) out
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Bills at Lions picks and predictions
Prediction
Bills 24, Lions 20
Moneyline
I’m taking Buffalo here. They’re getting Kincaid back, despite his questionable tag, and WR Keon Coleman (wrist) returns as well. Allen is playing on another level right now as he seeks his first MVP award. The Lions have been off for 10 days and don’t really need to be as hungry at 12-1.
Take the BILLS +120.
Against the spread
I’d consider the Bills’ side of the spread if it swells to 3.5 by kickoff. There’s no point in taking it here, though. Instead, give me JOSH ALLEN ANYTIME TOUCHDOWN (+115). He has one in 4 straight games and 6 during that span.
Over/Under
I like the Under here in a defensive struggle. The Lions are 2-3-1 O/U in their last 6. Buffalo is 4-0-1 in its last 5, but that’s thanks to scoring 30+ points in 7 straight games. That’s not happening here.
Take the UNDER 54.5 (-110).
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow Ryan Dodson on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.
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