Week 13’s Sunday Night Football game features the traveling San Francisco 49ers and the hosting Buffalo Bills. The 49ers began the 2024 season as one of the NFC’s favorites to make it to the Super Bowl. Due to injuries and uneven play, San Francisco entered the week with a disappointing 5 and 6 record. The 49ers are coming off a loss to the Green Bay Packers last weekend, 38 to 10. With their 9 and 2 record, the Bills come into this game with a very comfortable lead in the AFC East. The Bills are on a six-game win streak, including their win over the Chiefs two weeks ago, 30 to 21.
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San Francisco 49ers (5-6) 4th NFC West @ Buffalo Bills (9-2) 1st AFC East
- Kickoff: 8:20 p.m. EST, Sunday, December 1st
- Location: Highmark Stadium, Buffalo, New York
- TV Broadcast: NBC
- FANDUEL Sportsbook betting Odds: Bills -6.5; Point total: 44.5; Moneyline: Bills -275 | 49ers +225
—My Pick: The Bills to cover. The 49ers will have to travel cross country for this evening’s game and play in below-freezing conditions with blowing snow. These are the conditions that the Bills thrive in, while the San Francisco area is known for its year-round moderate temperatures. This game might be close at a neutral site but this game in these conditions should favor Buffalo in every way.
