One of the best runners in the league will be featured when James Cook and the Buffalo Bills visit the Indianapolis Colts on Sunday, November 10, 2024.

The Bills rank 16th in total offense (335.2 yards per game) and 17th in total defense (333.3 yards allowed per game) this season. The Colts rank 22nd in the NFL with 20.9 points per contest on offense, and they rank 12th with 21.4 points allowed per contest on the defensive side of the ball.

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Bills vs Colts: live streaming info, TV channel & game time

Bills vs Colts betting lines

NFL odds courtesy of BetMGM. Odds updated Saturday at 8:21 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

  • Spread Favorite: Bills (-3.5)
  • Moneyline: Bills (-206), Colts (+170)
  • Total: 46.5 points

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