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Here are two props that stand out ahead of Week 16 of the 2025 NFL season.

RB Derrick Henry, Baltimore Ravens: Over 17.5 rushing attempts

Henry is coming off one of the best performances of his Hall-of-Fame career in Week 17, carrying the ball 36 times for 216 yards and four touchdowns in a road victory against the Packers to help keep the Ravens’ season alive.

It was the seventh time in Henry’s career that he rushed for at least 200 yards, and his 36 attempts were a career high. Additionally, Henry topped 1,000 rushing yards after contact for the season, the fifth time he’s done so as an NFL player.

Thanks to some help from the Cleveland Browns last week, the Week 18 matchup between the Ravens and the Steelers will be a winner-take-all game for the AFC North title. Star quarterback Lamar Jackson sat out against Green Bay in Week 17 with a back injury but has been back at practice this week and is set to play in Week 18.

The All-Pro quarterback has not looked like himself while dealing with various injuries, as evidenced by his 70.0 PFF overall grade — his lowest grade since his rookie season in 2018 and only the 25th-best mark out of 40 qualifying quarterbacks this season.

Considering Jackson’s injury and potential ineffectiveness, as well as Henry’s performance down the stretch (averaging 134.5 rushing yards over the past four games), it’s hard to imagine the Ravens not handing the ball off to the running back early and often with their season on the line. When Baltimore played Pittsburgh back in Week 14, Henry carried the ball 25 times.

Given the magnitude of the game and Henry’s usual dominant production late in seasons, this is a prop I believe is far too low heading into Week 18.

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RB Christian McCaffrey, San Francisco 49ers: Over 111.5 rush+rec yards

The 13-3 Seattle Seahawks travel to take on the 12-4 San Francisco 49ers Saturday night in a game that has huge playoff implications. The winner will not only claim the NFC West division title, but they will also earn the No. 1 seed in the NFC playoffs.

The 49ers enter Week 18 on a six-game winning streak and have averaged 35.6 points per game over that span, thanks in large part to All-Pro running back Christian McCaffrey. McCaffrey’s usage has picked up down the stretch, leading to 26.4 touches per game over the past five weeks, including at least 20 rushing attempts in all five of those contests.

While McCaffrey is getting more opportunities in the run game, it’s his ability in the pass game that really stands out. Through Week 17, he leads all running backs in targets (114), receptions (96), receiving yards (890), touchdowns (seven) and PFF receiving grade (91.6). Seattle’s defense has allowed the most catches to running backs this season but has been stronger against the run, ranking third in the NFL in PFF run-defense grade (78.7).

In the teams’ first meeting in Week 1, McCaffrey turned 22 carries into 69 yards (3.1 average) and caught nine of 10 targets for 73 yards through the air. With 110 more receiving yards in Week 18, McCaffrey would become the first player in NFL history to record two seasons with at least 1,000 rushing and receiving yards. While unlikely, notching 110 receiving yards for a game is something McCaffrey has done three times in his career.

Considering McCaffrey’s usage down the stretch on the ground and his strong matchup against Seattle’s defense through the air, targeting his rushing-plus-receiving-yards prop makes the most sense for this crucial Week 18 matchup.