• Colby Parkinson put together the best game of his career: The Los Angeles Rams tight end has scored six touchdowns in his past six games, and a unique set of circumstances means he can go straight from the waiver wire into fantasy starting lineups.

• Monitor the injury report at running back: R.J. Harvey (ribs), Woody Marks (ankle), Devin Neal (hamstring) and Bam Knight (ankle) started in Week 15 and weren’t able to finish their games due to various injuries.

• Get PFF+ for 30% off: Use promo code HOLIDAY30 to unlock the PFF Player Prop Tool, Premium Stats, fantasy dashboards, the PFF Mock Draft Simulator, industry-leading fantasy rankings and much more — everything you need to win your season.

Another week of the 2025 NFL season is just about in the books. Here are the players you should be targeting in your fantasy football leagues, including options for smaller leagues and deeper leagues, as well as players to avoid.

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QUARTERBACK

Jacoby Brissett, Arizona Cardinals (Rostered in 44.3% of leagues on ESPN)

• League Size: 10
• Time Frame: Weeks 16 and 17

Brissett has been the Cardinals’ starting quarterback since Week 6 and will handle those duties for the rest of the season. From Weeks 6-13, he averaged 21.3 fantasy points per game, ranking fifth among quarterbacks. Despite his success, he was dropped in several leagues due to back-to-back rough matchups against the Los Angeles Rams and the Houston Texans, as well as five of the Cardinals’ top six wide receivers from the start of the season being out with injuries.

He was largely able to overcome the matchup in Week 14, completing 25 of 44 passes for 271 yards and two touchdowns, leading to 20.0 points and yet another top-12 finish. He similarly completed 27 of 40 for 249 and three touchdowns in Week 15, despite losing yet another one of his wide receivers.

Brissett faces the Atlanta Falcons and Cincinnati Bengals over the next two weeks. The matchup against Atlanta is above average, and it’s better than that of the other best quarterbacks available in at least 50% of ESPN leagues, such as Trevor Lawrence and Sam Darnold. The Bengals are a bottom-three team at preventing fantasy points to quarterbacks, so Brissett could be a top-five option in that game.

Trevor Lawrence, Jacksonville Jaguars (47.2%)

• League Size: 10
• Time Frame: Weeks 16 and 17

Lawrence had the best statistical game of his NFL career in Week 15, completing 20 of 32 passes for 330 yards and five touchdowns and running five times for 51 yards and a sixth score. He’s been the top quarterback available on the waiver wire over the past month, despite a less-than-ideal schedule and consistent injuries at wide receiver. He now ranks seventh on the season in fantasy points per game among quarterbacks — and third since Week 5, behind only Josh Allen and Jaxson Dart.The only problem is that the Jaguars have the third-worst schedule for quarterbacks over the final two weeks, playing the Denver Broncos and the Indianapolis Colts. However, Lawrence has thrown for at least 220 yards and multiple touchdowns in each of his past four games. He is playing so well that he will be among the top quarterbacks each of the next two weeks despite the matchups, making him a borderline fantasy starter.