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Game Overview

The Eagles and Chargers both face some uncertainty regarding the health of key contributors to the lineup. This matchup could hinge on who is missing more players. 

For the Chargers, the status of Justin Herbert, who recently underwent a procedure on his non-throwing hand, will be critical. Without Herbert, the Chargers would be left to start Trey Lance behind a patchwork offensive line that has struggled to keep quarterbacks off the ground this season, having allowed the most quarterback knockdowns (102) in the NFL.

However, the expected return of first-round running back Omarion Hampton to the lineup may do a lot to help take the pressure off the Chargers’ passing game. Prior to Hampton’s injury in Week 5, the first-year back held the fourth-highest PFF rushing grade (83.3) in the NFL. That asset helped the Chargers to cover three of their first five games with Hampton playing. 

For the Eagles, injuries have hit hard on both sides of the ball, with both Jalen Carter and Lane Johnson ruled out for Week 14. Needless to say, those losses will prove difficult to overcome. The betting markets back that up, with the Eagles holding an 0-4 record against the spread in the games in which either has missed — including each of the last two weeks, which Johnson was absent. Now, Philadelphia will have to navigate missing both standouts.

That key fact is one that betting analyst Ben Linsey highlighted this week on the PFF Betting Show with his pick of Chargers moneyline. The line has continued to move toward the Chargers, but still profiles as an angle the PFF simulation model agrees with, holding a 2.8% expected value.

Explore Top Player Props

WR A.J. Brown, Philadelphia Eagles: Under 62.5 receiving yards (-114)

Brown’s recent revival has been a positive turn for this Eagles offense, with the veteran receiver racking up 110-plus yards through the air in each of the last two games. Yet, those performances came against a pair of struggling secondaries in the Cowboys and Bears. This matchup with the Chargers’ defense presents a significantly more difficult task.

The Chargers have done well to limit production from receivers this season, surrendering the third-fewest yards to the position in 2025. This unit is particularly strong containing pass-catchers from wide alignments, allowing just 7.0 yards per coverage target — also the third-lowest mark in the NFL.

Los Angeles’ defense also deserves credit for its ability to keep plays in front of it and neutralize explosive catches. The Chargers’ 46 receptions of 15 or more yards surrendered ranks atop the NFL.

To add even more difficulty to this task, this matchup doesn’t bode well schematically for Brown. The Chargers run the fourth-highest rate of zone coverage, with a focus on Cover-3 and quarters. Brown is notably less effective when facing zone coverage compared to man, holding the second-biggest difference in PFF receiving grade between the two.