There is a buzz alive in Indianapolis heading into Sunday’s Week 6 matchup against the Arizona Cardinals and the result may show if the optimism is built to last.
The Colts sit atop the AFC standings after racing out to a 4-1 start, showing that this revamped team can do more than just compete. This stampede sporting blue throttles opponents, outscoring teams 143-62 across their four wins.
The dominance delivered in the first month of the 2025 season was punctuated by blowouts that remind the league how dangerous the Colts can be when clicking on both sides of the ball. Indianapolis holds an NFL-best plus-74 point differential that started with a 33-8 thrashing of the Miami Dolphins in the season opener, which tied the largest win margin in Lucas Oil Stadium history.
Colts head coach Shane Steichen orchestrated an offense that reached the end zone on six straight possessions last week, which tied the franchise’s longest scoring streak in 30 years. The 40-6 demolition of the Las Vegas Raiders last Sunday set a new record for the Colts’ largest win margin inside Lucas Oil Stadium.
The Colts have scored on 30 out of 44 true possessions, which is the highest rate in the league. Indianapolis ranks second in the NFL averaging 32.6 points per game and 6.3 yards per play, which is a testament to the creativity and execution that define Steichen’s thriving run-pass-option system.
At the heart of Indy’s steamrolling offense is star running back Jonathan Taylor, who leads the league with 480 rushing yards and six touchdowns on 94 carries. The sixth-year veteran marked his 13th career game with multiple touchdowns in Sunday’s rout of the Raiders.
Quarterback Daniel Jones was brought in as the eighth different Week 1 starter in the last nine seasons with hopes to finally discover some stability under center. And thus far, Jones has surpassed most expectations thriving on efficiency and smart decision making while running play action. Despite ranking just 16th in pass attempts, Jones sits third in the NFL with 1,290 passing yards. The Colts rank fourth averaging 253 passing yards per game.
Receiver Michael Pittman Jr., the veteran leader of Indy’s receiving corps, is tied for fifth in the league with four touchdown grabs, including scores in three straight games for the second time in his career. Rookie tight end Tyler Warren has quickly emerged as one of the NFL’s biggest hits from the 2025 NFL Draft and should already be considered an elite player at his respective position. Warren leads all NFL tight ends with 307 receiving yards on 23 catches, averaging an impressive 13.3 yards per catch. Indy’s first round draft pick has breached the end zone with a run, with a catch and while deployed as the lead blocker for Taylor.
As the focus shifts to stopping Arizona’s own talented pass-catcher duo of Marvin Harrison Jr. and Trey McBride, Cardinals quarterback Kyler Murray is officially listed as questionable while dealing a foot injury. Harrison is the son of Hall of Fame receiver Marvin Harrison Sr., who set franchise records with 1,102 receptions, 14,580 receiving yards and 128 touchdowns across 13 seasons in Indianapolis. The Colts’ secondary will have its hands full while playing without veteran cornerback Kenny Moore II, who will miss his third straight game while dealing with a delicate Achilles injury.
The Cardinals visit Indy coming off three consecutive heart-breaking losses by a combined five points. Cardinals head coach Jonathan Gannon will oppose Steichen for the first time since they both were coordinators leading the Philadelphia Eagles to an appearance in Super Bowl LVII.
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