• Brian Daboll’s Giants are no strangers to being home underdogs: Since hiring Daboll as head coach in 2022, the Giants have been the betting underdog in MetLife Stadium 23 times. That’s the most by any active head coach over that span.

• Cam Skattebo’s impact in the receiving game: The first-year running back has ample opportunity to leave his mark on this matchup amid a slew of injuries to the Giants’ pass-catchers. This makes his 2.5 receptions line very attainable.

• Subscribe to PFF+: It’s quick and easy. You’ll unlock industry-leading rankings, unlimited Fantasy Mock Draft Simulator use, the PFF Live Draft Assistant and our weekly Start/Sit Optimizer. It’s time to win.

Philadelphia Eagles (-7.5) vs New York Giants [Total: 40.5]

Game Overview

We kick off Week 6 with an NFC East showdown between the defending Super Bowl champion Eagles, fresh off their first loss of the 2025 season, and a Giants team looking to build momentum behind its young core.

This matchup has been lopsided in recent years, with Philadelphia dominating the rivalry. Since Brian Daboll took over as head coach in 2022, the Eagles have gone 6-1 straight up against the Giants. However, betting outcomes have been more evenly split. The Giants are 3-4 against the spread during that stretch — all as underdogs — while Philadelphia has covered just two of the four matchups in which it was favored by 7 or more points.

The 2025 season has followed a familiar script for the Eagles — favored in every game so far, they’ve posted a 3-2 record against the spread. That modest cover rate is more impressive when you consider the difficulty of their schedule, which has included four consecutive matchups against 2024 playoff teams. That stretch featured road covers in both Kansas City and Tampa Bay.

Philadelphia remains a top-tier team, powered by a defense that ranks fifth in overall grade (75.2). However, offensive efficiency has regressed, leading to tighter contests often decided by slim margins or pivotal special teams plays. The Eagles rank outside the league’s top half in several key offensive categories: 25th in positive EPA play rate, 19th in success rate and 23rd in scoring drive percentage.

For the Giants, betting markets have trended in the opposite direction — they’ll enter Week 6 as underdogs for the sixth consecutive game to start the season. No team has been a home underdog more frequently than New York under Brian Daboll, whose 23 such games since 2022 lead all active head coaches. They sit at 2-3 against the spread this year, with their lone outright win coming at home against the Chargers in Week 4.

If the Giants are going to pull off the upset, they’ll need a big performance from their pass rush — the NFL’s seventh-highest graded unit (80.0). The Eagles may be without guard Landon Dickerson, who exited Week 5 with an ankle injury. Without him, Philadelphia’s protection faltered, surrendering six sacks and a 35.6% pressure rate to Denver’s defensive front.

RB Cam Skattebo, New York Giants: Over 2.5 receptions (+120)

Skattebo has taken the NFL by storm, quickly becoming an indispensable piece of the Giants’ offense — a role that’s only grown more critical amid mounting injuries at wide receiver.

With Malik Nabers lost for the season in Week 4 and Darius Slayton sidelined last week (and likely this week), New York enters a tough matchup shorthanded and likely playing from behind.

That sets the stage for Skattebo to see continued involvement in the passing game, much like he did against the Saints when he caught all six of his targets, tying Theo Johnson for the team lead. It marked his second six-catch performance since his role expanded.

While Tyrone Tracy’s return may eat into Skattebo’s early-down work, it’s unlikely to impact his usage as a receiver. Skattebo holds the third-highest PFF receiving grade (81.6) among running backs this season — a stark contrast to Tracy’s 39.9 mark since the start of last year.