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Week 3 is nearly a wrap, and betting lines are now available for Week 4. Here are our favorite early spread picks for the slate.

Seattle Seahawks (+1.5) @ Arizona Cardinals [Total: 43.5]

After stumbling at home to start the season, the Seahawks have enjoyed a pair of dominant follow-up performances, now standing at 2-1 against the spread. Seattle easily covered as touchdown favorites at home against the Saints in Week 3, putting the game away before the end of the first half. 

This is a complete football team, seeing contributions from all three phases. Jaxon Smith-Njigba has been unguardable (4.61 yards per route run), Josh Jobe has clamped opposing receivers (27.7 passer rating allowed) and Sam Darnold is orchestrating the offense to near perfection (1.2% turnover-worthy play rate). The list goes on. The team isn’t beating itself.

Conversely, the Cardinals have been hit hard by injuries, but even harder by mistakes. Penalties, missed opportunities and conservative play calling have underscored their struggles. 

Injuries in the secondary limit Arizona’s defensive upside, which presents a good opportunity for Seattle’s play-action-focused offense. The Cardinals‘ defense has struggled with play-action looks, having allowed a 100% completion rate and a 142.8 passer rating on such plays. That sets up Darnold, who owns an 88.0 PFF passing grade on play action, for a big day.

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Indianapolis Colts (+3.5) @ Los Angeles Rams [Total: 48.5]

The Colts continued to hum on offense in Week 3, putting up another 40 points on the Tennessee Titans. And while they did punt for the first time in three games, it is still hard to overlook their success and lack of injuries. The Colts’ offense seems like the real deal. Quarterback Daniel Jones leads the NFL in yards per attempt, and Indianapolis’ offense ranks right behind the first-place Bills in expected points added per play.

The Rams’ defense has been solid from a production standpoint, but matchups against the Texans, Titans and Eagles — whom they just allowed 33 points to — are not exactly imposing from a defensive perspective.

The Colts might just be a well-rounded squad. If we look back in a month at how this game was priced, I bet we would be pricing it very differently.