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49ers might be forced to go another rung lower on RB depth chart

49ers might be forced to go another rung lower on RB depth chart
Photo by Kevin Sabitus/Getty Images

After losing Christian McCaffrey and Jordan Mason, Isaac Guerendo may also miss Thursday night

In the span of a week, the San Francisco 49ers are watching their running backs drop like flies.

Superstar Christian McCaffrey was shut down for the season following a Week 13 snow game against the Buffalo Bills. He suffered a knee injury after missing the start of the season with Achilles tendinitis.

But the 49ers lost another running back following the game in Buffalo. Jordan Mason, who entered the year as the starter in place of McCaffrey, is now on injured reserve and likely to miss the remainder of the season. He’ll finish 2024 with an impressive 789 yards and three touchdowns while not finishing the year and spending time behind McCaffrey on the depth chart.

Another layer of complication for San Francisco

The bad injury luck didn’t stop at Mason for the 49ers.

Isaac Guerendo, who San Francisco selected in the fourth round out of Louisville after trading two fifth round picks to the New York Jets, suffered an ankle sprain in the team’s most recent game versus the Chicago Bears and is likely to miss Thursday night’s game against the Los Angeles Rams barring “notable progress”.

The 49ers released their first injury report of the week, and they’ve listed Guerendo as a non-participant.

Who is the next man up?

Patrick Taylor replaced Guerendo versus the Bears. He’s a former undrafted free agent that played three years with the Green Bay Packers. The 49ers released Taylor roughly a month ago—while McCaffrey was nearing full health—and now could turn to him as the starter in a primetime game.

In Week 14 against the Bears, Taylor rushed seven times for 25 yards and scored a touchdown. San Francisco won convincingly 38-13.

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Our blog is all about curating the best stories, insights, and updates on your favorite teams. Whether you’re a passionate fan or just love the game, SportSourcio is here to keep you connected with what’s happening on and off the field.

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