Roquan Smith is set to miss his first game as a member of the Baltimore Ravens, as Adam Schefter is reporting that the All-Pro linebacker will be inactive with a hamstring injury.

On Sunday, Smith missed his fourth straight practice of the week after exiting the Ravens’ loss to the Steelers midway through the second half. Smith has never missed a game as a Raven because of injury.

Trenton Simpson, Malik Harrison, and Chris Board will have to be physically and efficiently able to defend against a Chargers offense led by star quarterback Justin Herbert and a rushing attack featuring former Ravens J.K. Dobbins and Gus Edwards.