The Buffalo Bills will host the Kansas City Chiefs in their upcoming Week 11 matchup.

Even though these two teams are extremely familiar with one another, it will still be the games, within the game, that will make all the difference.

Here are three key matchups to watch during Sunday’s Bills-Chiefs contest:

Bills running backs vs. Chiefs front seven

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The Bills have enjoyed a resurgence in their running game this year. James Cook has had 80 or more rushing yards in three of his last five games, and he has five rushing touchdowns over that stretch. Buffalo has found a true complement to Josh Allen’s passing game. But, rushing yards should be tougher to come by this week.

The Chiefs allow the third-fewest rushing yards per game this year (83.2). And, advanced metrics back up their play, too. Kansas City ranks second in the NFL in defense rushing DVOA.

Whoever wins this matchup will play a big role in the game. If the Bills can run the ball effectively, it will open up anything they want to do on offense. If they can’t, they’ll have to rely on the arm and legs of Allen.

DE Greg Rousseau vs. LT Wanya Morris

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Kansas City’s left tackle has had his struggles this year, and he’s coming off a knee injury in Week 10. Rousseau, on the other hand, is having his best season as a pro.

Morris ranks as the 62nd-best offensive tackle in the NFL according to Pro Football Focus, while Rousseau grades as the eighth-best pass rusher among edge defenders.

Rousseau has just 5.5 sacks through ten games, but he has been consistently getting after the passer. He ranks fourth in the NFL with 19 QB knockdowns and is tied for 10th in the NFL with 22 pressures.

Patrick Mahomes vs. the second level of Bills’ D

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The Chiefs quarterback loves to get the ball out quickly in head coach Andy Reid’s offense. They put a lot of trust in their skill players to catch underneath passes and produce yards after the catch. In turn, this puts a lot of stress on Bills defenders to make plays in space.

More specifically, Buffalo’s linebackers (and slot corner Taron Johnson) will have their hands full while trying to stop the run, cover the pass, and make sound tackles in space.

When these teams met in the divisional round of last season’s playoffs, the Bills were without Terrel Bernard in the middle of the defense. They had trouble on defense in that game, so we will see what kind of difference Bernard can make in this rivalry.