The Buffalo Bills will host the Arizona Cardinals in their upcoming Week 1 matchup.

Even with it being a cross-conference clash, it will still be the games, within the game, that will make all the difference.

Here are three key matchups to watch during Sunday’s Bills-Cardinals contest:

CB Rasul Douglas vs. WR Marvin Harrison Jr.

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While there will be tons of excitement in Buffalo watching the Bills’ top rookie draft pick, wide receiver Keon Coleman, there is another rookie wideout worth watching on Sunday. It’s Marvin Harrison Jr.

The Cardinals are hoping his skillset instantly makes their offense better. That’s why he was the first non-quarterback selection at the 2024 NFL draft.

Douglas returns as Buffalo’s top cornerback this season. The Bills will hope Harrison’s NFL successes do not begin until Week 2.

DE Greg Rousseau vs. OL Paris Johnson

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With the uncertainty facing Von Miller, the departure of Leonard Floyd, and Rousseau moving another year into his career… this needs to be his season to shine. The Bills will hope he’s going to hit double-digit sacks in 2024 and his first test is Johnson, the Cards’ former right tackle now turned left tackle.

WR Khalil Shakir vs. CB Garrett Williams

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Shakir will lineup plenty in the slot where Williams will defend. Shakir is also the only returning Bills wide receiver that has caught a pass from quarterback Josh Allen in the regular season. He needs to step up in the early stages of 2024.